WHAT IS Ventrilia?

Ventrilia is a new generation genetic test that analyzes 292 genes to detect mutations that cause multiple cardiovascular conditions with complex phenotypes. By identifying genetic mutations that could cause cardiovascular diseases, Ventrilia can provide you with comprehensive genetic insight about your patient’s cardiovascular health and guide you towards an optimal clinical management plan.

Ventrilia CAN BE USED TO:

  • Identify the genetic variant in symptomatic individuals with a clinically diagnosed cardiovascular condition
  • Identify the genetic variant in presymptomatic individuals with a clinically diagnosed cardiovascular condition
  • Identify the genetic variant in asymptomatic individuals that belong in high-risk groups

ADVANTAGES OF Ventrilia INCLUDE:

  • Assessment of clinically actionable mutations
  • Proven technology
  • Superior targeted genomic analysis
  • Easy to interpret results
  • Competitive turn-around time
  • Informed clinical management
  • Non-Invasive sample collection

CARDIOVASCULAR DISEASE PANELS

Ventrilia tests for autosomal recessive, autosomal dominant, and X-linked cardiovascular diseases.

  • AORTOPATHY

    48

  • ARRHYTHMIA

    42

  • CARDIOMYOPATHY

    98

  • CONGENITAL HEART DEFECTS (CHD)

    80

  • FAMILIAL HYPERCHOLESTE­RO­LEMIA (FH)

    11

  • PULMONARY HYPERTENSION (PH)

    11

  • RASOPATHIES

    30

  • COMPREHENSIVE

    292

ARRHYTHMIA PANEL

Arrhythmia refers to irregular, too fast, or too slow heartbeat caused by the improper working of the electrical impulses that coordinate the heartbeat. Arrhythmia related diseases include: Atrial Fibrillation, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Long QT Syndrome, Short QT Syndrome

Number Of Genes Tested

42

CARDIOMYOPATHY PANEL

Cardiomyopathy is a group of diseases of the heart muscle (myocardium) which reduces the efficiency of the heart to pump blood. Cardiomyopathy related diseases include: Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathy with onset in neonatal period, infancy or childhood, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Non-Compaction Cardiomyopathy, Restrictive Cardiomyopathy

Number Of Genes Tested

98

CONGENITAL HEART DEFECTS (CHD) PANEL

Congenital heart defects are present from birth and affect the heart’s structure and efficiency to function. CHD related diseases include: Atrioventricular Septal defect, Atrial Septal defect, Ventricular Septal defect, Aortic Stenosis, Tetralogy of Fallot.

Number Of Genes Tested

80

RASOPATHIES PANEL

RASopathies are a group of genetic conditions that affect the RAS-MAPK pathways and lead to developmental syndromes. RASopathies related diseases include: Cardio-Facio-Cutaneous Syndrome, Costello Syndrome, Legius Syndrome, Neurofibromatosis Type 1, Noonan Syndrome, Noonan with multiple lentigines

Number Of Genes Tested

30

AORTOPATHY PANEL

Aortopathy refers to a group of diseases that affect the aorta, causing enlargement, dissection or aortic aneurysm. Aortopathy related diseases include: Marfan Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, Familial Thoracic Aortic Aneurysms and Dissections, Bicuspid Aortic Valve Disease.

Number Of Genes Tested

48

FAMILIAL HYPERCHOLESTEROLEMIA (FH) PANEL

Familial Hypercholesterolemia is a common inherited genetic disorder that causes high levels of LDL and could lead to heart disease and heart attacks, if untreated.

Number Of Genes Tested

11

PULMONARY HYPERTENSION (PH) PANEL

Pulmonary Hypertension refers to the high blood pressure in the arteries of the lungs and the right side of the heart.

Number Of Genes Tested

11

COMPREHENSIVE PANEL

The comprehensive panel includes all 292 genes tested in the disease panels.

Number Of Genes Tested

292

For a complete list of 292 genes tested by Ventrilia, please click here.

WHY RECOMMEND Ventrilia TO MY PATIENTS?

Cardiovascular diseases are the leading cause of illness and death worldwide, responsible for 31% of all global deaths*. Previously, assessment of the disease risk was based on the lifestyle of an individual. The role of genetic testing is now becoming increasingly important. Genetic testing can detect the underlying condition, provide a prognosis and identify at-risk family members, who might be predisposed to the same cardiovascular disease. Identification of a genetic mutation that causes a disease, can lead to an improved prognosis as well as effective clinical management and treatment for many cardiovascular conditions†.

Cardiovascular genetic testing is highly recommended by professional societies such as the American College of Cardiology (ACC), American Heart Association (AHA), and the European Society of Cardiology (ESC).

* World Health Organization (Cardiovascular Diseases fact sheets) and World Heart Federation (2017)

† Clinical Appropriateness Guidelines - Genetic Testing for Hereditary Cardiac Disease - developed by Informed Medical Decisions, Inc.(2019)

WHAT IS THE ROLE OF CARDIOVASCULAR GENETIC TESTING?

IDENTIFY

  • Genetic mutations involved in cardiovascular conditions
  • Complex cardiovascular diseases
  • The correct disease by differentiating between diseases with similar phenotype

EVALUATE

  • Patient's level of risk
  • Treatment options
  • At-risk family members

MANAGE

  • Clinical care
  • Decision-making before an invasive treatment
  • Specific therapies and predict their response

WHO IS Ventrilia FOR?

Symptomatic patients with an unidentified cardiovascular genetic disorder

Presymptomatic patients with family history of inherited cardiovascular disease or sudden cardiac death

Patients experiencing fainting or unexplained seizures

Patients with clinical diagnosis of aortic defect, or irregular cardiovascular anatomy

Patients with clinical diagnosis of channelopathies (irregular heart rhythm)

Patients suspected of having a cardiovascular-associated genetic condition due to clinical symptoms (shortness of breath, excessive sweating, heart pain, weakness)

Patients in high-risk groups (eg. high cholesterol) with non-specific phenotype

TECHNOLOGY YOU TRUST

Ventrilia uses a targeted genomic analysis and a robust, validated multiengine analysis platform to screen for clinically actionable, highly penetrant gene mutations with high sensitivity and specificity.

TARGETED TECHNOLOGY

Ventrilia is based on a novel, target capture enrichment technology that has been thoroughly validated for its accuracy and precision.

FULL COVERAGE

Ventrilia screens for all coding regions on the genes of interest, increasing the chances of identifying any pathogenic or likely pathogenic mutations: single nucleotide variants, small insertions and deletions, and copy number variants.

NOVEL BIOINFORMATICS

Innovative bioinformatics pipelines analyze the sequencing data produced from each sample, increasing the sensitivity and specificity of Ventrilia.

WHAT WILL THE REPORT TELL ME?

  • Result on mutations tested
  • Thorough interpretation and clinical significance of variants

Carrier status will not be reported for recessive conditions. Re-interpretation of variants of uncertain significance will be performed at routine intervals.

HOW DOES Ventrilia HELP ME?

Overlapping symptoms make it very challenging to clearly identify the underlying cardiovascular condition. There are many types of congenital cardiovascular diseases, ranging from simple to complex defects with severe, life-threatening symptoms.

Ventrilia can detect mutations that cause cardiovascular diseases and help you choose an ideal treatment based on the specific mutation, develop a better clinical management plan and reduce your patient's risk of sudden cardiovascular events such as stroke or heart attack.

For high-risk, asymptomatic individuals with a cardiovascular genetic mutation, you can recommend appropriate examinations at key time intervals. Additionally, you can inform any family members who might also have the same genetic mutation. Early intervention can potentially be lifesaving for symptomatic, presymptomatic and asymptomatic individuals.

WHAT ARE THE BENEFITS OF Ventrilia FOR MY PATIENTS?

  • Faster identification of complex cardiovascular conditions
  • Accurate detection of multiple cardiovascular genetic mutations
  • Early identification in asymptomatic patients
  • Improved prognosis
  • More effective treatment
  • Better clinical care
  • Prevention of potential sudden onset of cardiovascular conditions, including sudden death in all patients

HOW TO ADMINISTER Ventrilia?

  • RECOMMEND THE IDEAL PANEL TO YOUR PATIENT
  • COLLECT A BUCCAL SWAB FROM YOUR PATIENT
  • SEND THE SAMPLE TO NIPD Genetics
  • THE SAMPLE WILL BE ANALYZED IN OUR LABORATORY
  • RESULTS WILL BE SENT TO YOU WITHIN 2-4 WEEKS FROM SAMPLE RECEIPT

NIPD Genetics - Privacy Policy

General Statement

NIPD Genetics is a leading, innovative biotechnology company that designs, develops, and provides a broad spectrum of healthcare services to its customers through its expansive portfolio of molecular and clinical laboratory tests in all disciplines.

At NIPD Genetics we are committed to protecting and respecting our customer’s privacy and personal information. Personal information or personal data means any information that identifies, relates to, describes, is capable of being associated with, or could be reasonably linked, directly or indirectly, with a particular individual, such as name, identification number, location data, an online identifier or to one or more factors specific to the physical, physiological, genetic, mental, economic, cultural or social identity of that individual.

NIPD Genetics collects and processes your personal information according to the General Data Protection Regulation (EU) 2016/679 and the Cypriot law providing for the protection of natural persons with regards to the processing of personal data and for the free movement of such data (L. 125(I)/2018). The following principles lie at the heart of our approach to handling personal data:

NIPD Genetics has appointed a Data Protection Officer (DPO) who is responsible for overseeing and ensuring that personal information is collected and processed in line with these principles. The contact details of the Data Protection Officer (DPO) can be found below:

Email address: dpo@nipd.com

Postal address: 31 Neas Engomis street, 2409 Engomi, Nicosia, Cyprus

Telephone number: + 357 22266888

By accessing or using our products or services, or by transmitting information to us by email or other electronic means, you accept our policies, procedures and practices described in this Privacy Policy. If you do not agree with our policies, procedures and practices as described, you can choose not to access or use our products or services or not to transmit personal information to us.

This Privacy Policy applies to NIPD Genetics facilities, its websites www.nipd.com, www.nipdlabs.com, www.nipdlabs.com.cy and their subdomains, that link to this privacy pol icy.

PERSONAL INFORMATION COLLECTION AND PROCESSING

We collect and process several types of personal information from and about users of our websites and of our products and services, including:

Information about children

If you are under 18 years of age, do not register on our website or provide any information about yourself to us. We do not provide our products or services directly to children or proactively collect their personal information. Despite this prohibition, it is possible that we may sometimes be given information about children while handling samples from our customers in our clinical labs, or through use of our products and services by our customers and partners. If we become aware that we have inadvertently collected personal information from children under the age of 18, without parental consent, we will take the necessary steps to delete it as soon as possible in compliance with applicable laws.

LEGAL BASIS FOR PROCESSING OF YOUR PERSONAL INFORMATION

Your personal information is collected by NIPD Genetics for the following purposes:

  1. To provide you with our products and services, respond to your inquiries or fulfill your requests and otherwise manage your relationship with us. The legal basis for processing is to meet the requirements of a contract, to comply with our legal obligations and/or because we have a legitimate interest in responding to requests for information about our products and services.
  2. To communicate with you about content and product offerings, newsletters and event invitations which are relevant to your interests and in line with your preferences. The legal basis for processing is the individual’s explicit consent prior to sending the information and managing individuals preferences.
  3. To process and respond to complaints. The legal basis for processing is to meet a legal obligation.
  4. To monitor and record information relating to the use of our products and services, including our website. The legal basis for processing is our legitimate interest in order to improve our products and services and our website for individuals.

To provide our products and services, NIPD Genetics may collect, receive and process biological samples to isolate and sequence DNA. NIPD Genetics may then store resulting genetic information and use genetic information to provide our products and services. In some cases, NIPD Genetics may provide interpretations of genetic information on behalf of its customers, including healthcare providers. This is only done pursuant to a written contract or a Sample Information Form with a patient’s informed consent and is subject to applicable legal and ethical safeguards.

This sensitive information described above is collected by NIPD Genetics for the following purposes:

  1. To provide support and maintenance services to customers who use our products and services – The legal basis for processing is to meet the requirements of a contract.
  2. To provide genotyping and sequencing services and analysis for our customers, including healthcare providers. The legal basis of this processing is to meet the requirements of a contract or as allowed in the Sample Information Form with a patient’s informed consent.
  3. To conduct genotyping and sequencing services and analysis for quality control, process and product development and improvements, and optimization in our labs to reflect quality improvements and advances in our technology. The legal basis for processing is the patient’s informed consent given through the Sample Information Form.

Transfer of Data

Your information, including personal data, may be transferred to - and maintained on - computers located outside your province, country or other governmental jurisdiction where the data protection laws may differ than those from your jurisdiction.

If you are located outside Cyprus and choose to provide information to us, please note that we transfer the data, including personal data, to Cyprus and process it there.

Your consent to this Privacy Policy followed by your submission of such information represents your agreement to that transfer.

NIPD Genetics will take all reasonable steps necessary to ensure that your data is treated securely and in accordance with this Privacy Policy and no transfer of your personal information will take place to an organization or a country unless there are adequate controls in place including the security of your data and other personal information.

Disclosure of Data

NIPD Genetics complies with the General Data Protection Regulation and will not sell or trade your personal information.

NIPD Genetics may disclose your personal information in the good faith that such action is necessary:

COOKIES AND OTHER TRACKING TECHNOLOGIES

Cookies are files with small amount of data which may include an anonymous unique identifiers. Cookies are sent to your browser when you visit a website and stored on your device. Tracking technologies used on the website are beacons, tags and scripts, to collect and track information and to improve and analyze our websites.

We use cookies and similar tracking technologies to track the activity on our websites and collect certain information. This includes information about the computer or device you are using, such as Internet protocol (IP) address, information about the browser type or version, the pages of our website that you visit, the time and date of your visit, the time spent on those pages, unique device identifiers and other diagnostic data.

You can instruct your browser to refuse all cookies or to indicate when a cookie is being sent. However, if you do not accept cookies, you may not be able to use some portions of our websites.

Examples of Cookies we may use:

Session Cookies. We use Session Cookies to operate our websites.

Preference Cookies. We use Preference Cookies to remember your preferences and various settings.

Security Cookies. We use Security Cookies for security purposes.

Visitor behavior cookies. To understand how visitors use and navigate the websites

Keyword cookies. To understand how visitors discover the websites.

ANALYTICS

We may use third-party Service Providers to monitor and analyze the use of our websites.

Google Analytics

Google Analytics is a web analytics service offered by Google that tracks and reports website traffic. Google uses the data collected to track and monitor the use of our service. This data is shared with other Google services. Google may use the collected data to contextualize and personalize the ads of its own advertising network.

You can opt-out of having made your activity on the Service available to Google Analytics by installing the Google Analytics opt-out browser add-on. The add-on prevents the Google Analytics JavaScript (ga.js, analytics.js, and dc.js) from sharing information with Google Analytics about visits activity.

For more information on the privacy practices of Google, please visit the Google Privacy & Terms web page

SECURITY OF DATA

We are committed to protecting the security of the information we collect, and we take reasonable physical, technical, and administrative safeguards such as data anonymization and encryption to help protect personal information from unauthorized or inappropriate access or use. It is your responsibility to protect the confidentiality of your passwords, and any other access features associated with your access or use of the website or our products and services, as well as to adhere to any applicable Terms of Use or other contract between us and you or your organization.

PERSONAL DATA RETENTION

We may retain collected information even after you remove it from the website, our Services, or our Products, to comply with applicable law, to resolve disputes, to enforce any rights in connection with the website, our Services, or our Products, and to use as provided in this Privacy Policy, the Terms of Use, or an applicable contract between us and you or your organization. How long we retain specific personal information varies depending on the purpose for its use and we may delete or retain your personal information in accordance with applicable law.

SERVICE PROVIDERS

We may employ third party companies and individuals to facilitate, maintain or operate our websites (“Service Providers”), to provide the websites on our behalf, to perform service-related services or to assist us in analyzing how our websites are used.

These third parties have access to your Personal Data only to perform these tasks on our behalf and are obligated not to disclose or use it for any other purpose.

LINKS TO OTHER SITES

Our websites may contain links to other sites that are not operated by us. If you click on a third-party link, you will be directed to that third party's site. We strongly advise you to review the Privacy Policy of every site you visit.

We have no control over and assume no responsibility for the content, privacy policies or practices of any third-party sites or services.

CHANGES TO THIS PRIVACY POLICY

This Privacy Policy may be updated from time to time. We will notify you of any changes by posting the new Privacy Policy on this page.

We will let you know via email and/or a prominent notice on our website, prior to the change becoming effective and update the “effective date” at the bottom of this Privacy Policy.

You are advised to review this Privacy Policy periodically for any changes. Changes to this Privacy Policy are effective when they are posted on this page.

YOUR LEGAL RIGHTS

NIPD Genetics ensures that it can respond immediately to requests that you make for the exercise of your legal rights in accordance with data protection laws. These rights are as follows:

You also have the right to lodge a complaint at any time to the Office of the Commissioner for Personal Data Protection.

We encourage you to contact us, should you wish to practice any of your legal rights or you have any questions about this Privacy Policy, by sending an email to NIPD Genetics’ Data Protection Officer at dpo@nipd.com.

Effective date: 18/06/2021

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