WHAT IS Rodinia?

Rodinia is a new genetic test for infertility that screens for mutations in individuals who have difficulty achieving pregnancy. By identifying genetic variants associated with infertility and disorders of sex chromosomes, Rodinia can provide accurate prognostic assessment and identify the most applicable treatment options for each patient. Rodinia can help guide you towards an optimal treatment plan for any couple or individual wishing to have a child.


Rodinia offers a female and a male infertility panel. Each panel detects numerous genetic variants associated with infertility. Rodinia also detects whole, partial and mosaic sex chromosome changes.


55 genes, X chromosome aneuploidies

Screens for genetic variants associated with female infertility and includes disorders such as primary ovarian insufficiency, polycystic ovary syndrome, ovarian hyperstimulation syndrome and hypogonadotropic hypogonadism disorders such as Kallman syndrome.

Early interventions to preserve fertility: Early identification of women with primary ovarian insufficiency can determine the need for oocyte harvesting and cyropreservation at a young age to preserve fertility and enable the patient to have a child in the future.


40 genes, X and Y chromosome aneuploidies, including Y-chromosome microdeletions

Screens for genetic variants that can cause male factor inferitlity, including sex chromosome changes and hypogonadotropic hypogonadism disorders like Kallman syndrome.

Prognostic value for treatment: Azoospermic men have a higher prevalence of microdeletions on the Y-chromosome than men with normal sperm and should receive genetic testing to clarify etiology prior to treatment*. Of the 3 deletions that are associated with azoospermia, only one is associated with a chance of recovering sperm through testicular sperm extraction treatment (TESE).



22 genetic variants

Checks for specific genetic variants associated with recurrent pregnancy loss, to determine the need for taking treatment, such as hormonal therapy or anticoagulants, to reduce or prevent complications during pregnancy and delivery. Can be offered to all individuals and can be beneficial to couples that have had more than one miscarriage.

*Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion (2015)

For a complete list of the genes and diseases tested by Rodinia, please visit nipd.com/rodiniapanel

WHO IS Rodinia FOR?

Couples or individuals experiencing pregnancy delay
Individuals with specific phenotype indicating a genetic syndrome associated with a sex chromosome aneuploidy
Females with irregular or absent menstruation
Males with low sperm count, irregular sperm form, or movement
Any individual or couple that will undergo assisted reproductive technology (ART) treatment
Candidates for sperm or oocyte donation
Individuals with family history of infertility


Biochemical and instrumental testing, such as hormone checks, ultrasounds and semen analysis can identify up to 65% of infertility cases. If the cause of infertility remains undetermined, genetic testing can be offered as a significant number of infertility cases are attributed to genetic variants.

Up to 15% of men and up to 10% in women have a genetic mutation which is linked with infertility. Genetic testing can provide deep insight that acts as a valuable prognostic tool, and can guide you to take informed and accurate decisions on the best clinical management and treatment for your patient. Genetic testing could subsequently help increase the patient's chances for achieving a pregnancy.


Thoroughly validated target capture enrichment technology

X and Y chromosome analysis for whole copy number changes, and partial changes down to 10Mb

Mosaicism detection in sex chromosomes down to 15%

Full coverage of all coding regions, detecting single nucleotide variants, small insertions and deletions, and copy number variants

The add-on Haemophilia and Thrombosis panel targets specific variants

Novel bioinformatics for high sensitivity and specificity


  • Results on mutations tested
  • Thorough interpretation and clinical significance of variants detected
  • Reporting pathogenic and likely pathogenic variants, and variants of uncertain significance

Carrier status will not be reported for recessive conditions.


By identifying the underlying genetic cause of infertility, Rodinia can help you to:

Determine accurate prognosis for your patient

Evaluate and choose the most optimal treatment for your patient

Manage clinical care by being aware of potential complications, like ovarian hyperstimulation

Advice your patient on how to proceed with pregnancy planning

Recommend testing to family members, if applicable


Infertility is considered a major disorder of the reproductive system and it affects approximately 1 in 6 couples worldwide†

Rodinia uses robust and proven technology to detect mutations on genes associated with infertility and changes on sex chromosomes. Rodinia can provide important insight regarding the reproductive health of an individual and guide treatment options to help them achieve conception.

Early detection of the underlying genetic cause of infertility can act as a prognostic tool and be pivotal to the choice and outcome of treatment. Early detection can also determine the need for earlier interventions at a younger age, to preserve fertility.

Rodinia provides invaluable genetic insight which can guide you to create a more personalized approach for family planning for each couple or individual.


Superior targeted genomic analysis

Identifies genetic mutations associated with infertility

Assessment of clinically actionable mutations

Guides patient-specific clinical management and treatment

Enables accurate prognosis

Easy to interpret results

High precision and accuracy

†Agarwal A., et al., 'A unique view on male infertility around the globe'. Reproductive biology and endocrinology, 2015.



NIPD Genetics - Privacy Policy

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If, you do not agree with this Privacy Policy, please do not access or use any of NIPD Genetics Sites.

NIPD Genetics values your interest in NIPD Genetics, its products and its services. NIPD Genetics takes the protection of your data seriously.

Personal data for purposes of this Privacy Policy, is any information by which you can be individually identified, including, but not limited to, your name, profession, address, e-mail address, and telephone number.

You may contact NIPD Genetics Public Company Ltd at
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NIPD Genetics Data Protection Officer can be reached at dpo@nipd.com

This Privacy Policy applies only to the Sites as defined above and which are operated by NIPD Genetics. The NIPD Genetics Privacy Policy seeks to inform the users of its Sites of the following:

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