WHAT IS Rodinia?

Rodinia is a new genetic test for infertility that screens for mutations in individuals who have difficulty achieving pregnancy. By identifying genetic variants associated with infertility and disorders of sex chromosomes, Rodinia can provide accurate prognostic assessment and identify the most applicable treatment options for each patient. Rodinia can help guide you towards an optimal treatment plan for any couple or individual wishing to have a child.

WHAT DOES Rodinia TEST FOR?

Rodinia offers a female and a male infertility panel. Each panel detects numerous genetic variants associated with infertility. Rodinia also detects whole, partial and mosaic sex chromosome changes.

FEMALE INFERTILITY PANEL

55 genes, X chromosome aneuploidies

Screens for genetic variants associated with female infertility and includes disorders such as primary ovarian insufficiency, polycystic ovary syndrome, ovarian hyperstimulation syndrome and hypogonadotropic hypogonadism disorders such as Kallman syndrome.

Early interventions to preserve fertility: Early identification of women with primary ovarian insufficiency can determine the need for oocyte harvesting and cyropreservation at a young age to preserve fertility and enable the patient to have a child in the future.

MALE INFERTILITY PANEL

40 genes, X and Y chromosome aneuploidies, including Y-chromosome microdeletions

Screens for genetic variants that can cause male factor inferitlity, including sex chromosome changes and hypogonadotropic hypogonadism disorders like Kallman syndrome.

Prognostic value for treatment: Azoospermic men have a higher prevalence of microdeletions on the Y-chromosome than men with normal sperm and should receive genetic testing to clarify etiology prior to treatment*. Of the 3 deletions that are associated with azoospermia, only one is associated with a chance of recovering sperm through testicular sperm extraction treatment (TESE).

ADD-ON PANEL

HAEMOPHILIA AND THROMBOSIS PANEL

22 genetic variants

Checks for specific genetic variants associated with recurrent pregnancy loss, to determine the need for taking treatment, such as hormonal therapy or anticoagulants, to reduce or prevent complications during pregnancy and delivery. Can be offered to all individuals and can be beneficial to couples that have had more than one miscarriage.

*Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion (2015)

For a complete list of the genes and diseases tested by Rodinia, please visit nipd.com/rodiniapanel

WHO IS Rodinia FOR?

Couples or individuals experiencing pregnancy delay
Individuals with specific phenotype indicating a genetic syndrome associated with a sex chromosome aneuploidy
Females with irregular or absent menstruation
Males with low sperm count, irregular sperm form, or movement
Any individual or couple that will undergo assisted reproductive technology (ART) treatment
Candidates for sperm or oocyte donation
Individuals with family history of infertility

HOW DOES GENETIC TESTING HELP ME?

Biochemical and instrumental testing, such as hormone checks, ultrasounds and semen analysis can identify up to 65% of infertility cases. If the cause of infertility remains undetermined, genetic testing can be offered as a significant number of infertility cases are attributed to genetic variants.

Up to 15% of men and up to 10% in women have a genetic mutation which is linked with infertility. Genetic testing can provide deep insight that acts as a valuable prognostic tool, and can guide you to take informed and accurate decisions on the best clinical management and treatment for your patient. Genetic testing could subsequently help increase the patient's chances for achieving a pregnancy.

TECHNOLOGICAL ADVANCES

Thoroughly validated target capture enrichment technology

X and Y chromosome analysis for whole copy number changes, and partial changes down to 10Mb

Mosaicism detection in sex chromosomes down to 15%

Full coverage of all coding regions, detecting single nucleotide variants, small insertions and deletions, and copy number variants

The add-on Haemophilia and Thrombosis panel targets specific variants

Novel bioinformatics for high sensitivity and specificity

WHAT WILL THE REPORT TELL ME?

  • Results on mutations tested
  • Thorough interpretation and clinical significance of variants detected
  • Reporting pathogenic and likely pathogenic variants, and variants of uncertain significance
reports-image

Carrier status will not be reported for recessive conditions.

WHAT CAN I DO AFTER Rodinia ?

By identifying the underlying genetic cause of infertility, Rodinia can help you to:

Determine accurate prognosis for your patient

Evaluate and choose the most optimal treatment for your patient

Manage clinical care by being aware of potential complications, like ovarian hyperstimulation

Advice your patient on how to proceed with pregnancy planning

Recommend testing to family members, if applicable

WHY RECOMMEND Rodinia TO MY PATIENTS?

Infertility is considered a major disorder of the reproductive system and it affects approximately 1 in 6 couples worldwide†

Rodinia uses robust and proven technology to detect mutations on genes associated with infertility and changes on sex chromosomes. Rodinia can provide important insight regarding the reproductive health of an individual and guide treatment options to help them achieve conception.

Early detection of the underlying genetic cause of infertility can act as a prognostic tool and be pivotal to the choice and outcome of treatment. Early detection can also determine the need for earlier interventions at a younger age, to preserve fertility.

Rodinia provides invaluable genetic insight which can guide you to create a more personalized approach for family planning for each couple or individual.

Rodinia BENEFITS

Superior targeted genomic analysis

Identifies genetic mutations associated with infertility

Assessment of clinically actionable mutations

Guides patient-specific clinical management and treatment

Enables accurate prognosis

Easy to interpret results

High precision and accuracy

†Agarwal A., et al., 'A unique view on male infertility around the globe'. Reproductive biology and endocrinology, 2015.

HOW TO ADMINISTER Rodinia?

  • RECOMMEND Rodinia TO YOUR PATIENT
  • COLLECT A BUCCAL SWAB FROM YOUR PATIENT
  • SEND THE SAMPLE TO NIPD Genetics
  • THE SAMPLE WILL BE ANALYZED IN OUR LABORATORIES
  • RESULTS WILL BE SENT TO YOU WITHIN 2-4 WEEKS FROM SAMPLE RECEIPT

NIPD Genetics - Privacy Policy

General Statement

This Privacy Policy applies only to www.nipd.com and its subdomains (hereafter collectively referred to as “Sites") that link to this policy. NIPD Genetics Sites are owned by NIPD Genetics Public Company Ltd and are operated by NIPD Genetics Public Company Ltd and on occasion by a third-party that is responsible for the technical maintenance of the Sites.

If, you do not agree with this Privacy Policy, please do not access or use any of NIPD Genetics Sites.

NIPD Genetics values your interest in NIPD Genetics, its products and its services. NIPD Genetics takes the protection of your data seriously.

Personal data for purposes of this Privacy Policy, is any information by which you can be individually identified, including, but not limited to, your name, profession, address, e-mail address, and telephone number.

You may contact NIPD Genetics Public Company Ltd at
NIPD Genetics Public Company Ltd
Neas Engomis 31
Engomi, Nicosia
2409, Cyprus

NIPD Genetics Data Protection Officer can be reached at dpo@nipd.com

This Privacy Policy applies only to the Sites as defined above and which are operated by NIPD Genetics. The NIPD Genetics Privacy Policy seeks to inform the users of its Sites of the following:

NIPD Genetics will not use or share your information with anyone, except as described in this Privacy Policy. This Privacy Policy does not apply to any information we might collect by other digital and offline means and or from other digital and offline sources. The use of information collected through our Sites shall be limited to the purposes under this Privacy Policy and our Terms of Use to customers.

This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Sites and the choices you have associated with that data.

We use your data to provide and improve the Sites. By using the Sites, you agree to the collection and use of information in accordance with this policy. Unless otherwise defined in this Privacy Policy, terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, accessible from www.nipd.com

Type of personal information NIPD Genetics may collect through its Sites

Information Collection And Use

We collect several different types of information for various purposes to provide and improve our Sites and services to you.

Personal Data

While using NIPD Genetics Sites, you may be asked to provide NIPD Genetics certain personally identifiable information that can be used to contact or identify you ("Personal Information"). Personal Information that might be used to identify you includes, but is not limited to:

If you send us a query via our Contact us form, your email address, the content and any follow up emails are retained indefinitely.

Cookies and Usage Data

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We may also collect information how the Sites are accessed and used ("Usage Data"). This Usage Data may include information such as your computer's Internet Protocol address (e.g. IP address), browser type, browser version, the pages of our Sites that you visit, the time and date of your visit, the time spent on those pages, unique device identifiers and other diagnostic data.

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Cookies are files with small amount of data which may include an anonymous unique identifier. Cookies are sent to your browser from a website and stored on your device. Tracking technologies also used are beacons, tags, and scripts to collect and track information and to improve and analyze our Sites.

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Examples of Cookies we use:

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Your information, including personal data, may be transferred to — and maintained on — computers located outside of your province, country or other governmental jurisdiction where the data protection laws may differ than those from your jurisdiction.

If you are located outside Cyprus and choose to provide information to us, please note that we transfer the data, including personal data, to Cyprus and process it there.

Your consent to this Privacy Policy followed by your submission of such information represents your agreement to that transfer.

www.nipd.com will take all reasonable steps necessary to ensure that your data is treated securely and in accordance with this Privacy Policy and no transfer of your personal data will take place to an organization or a country unless there are adequate controls in place including the security of your data and other personal information.

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NIPD Genetics complies with the protection of personal data regulation and will not sale or trade your personal data.

NIPD Genetics may disclose your personal data in the good faith belief that such action is necessary to:

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The security of your data is important to us, but remember that no method of transmission over the Internet, or method of electronic storage is 100% secure. While we strive to use commercially acceptable means to protect your Personal Data, we cannot guarantee its absolute security.

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We may employ third party companies and individuals to facilitate, maintain or operate our Sites ("Service Providers"), to provide the SItes on our behalf, to perform service-related services or to assist us in analyzing how our Sites is used.

These third parties have access to your Personal Data only to perform these tasks on our behalf and are obligated not to disclose or use it for any other purpose.

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We may use third-party Service Providers to monitor and analyze the use of our Sites.

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Google Analytics is a web analytics service offered by Google that tracks and reports website traffic. Google uses the data collected to track and monitor the use of our Service. This data is shared with other Google services. Google may use the collected data to contextualize and personalize the ads of its own advertising network.

You can opt-out of having made your activity on the Service available to Google Analytics by installing the Google Analytics opt-out browser add-on. The add-on prevents the Google Analytics JavaScript (ga.js, analytics.js, and dc.js) from sharing information with Google Analytics about visits activity.

For more information on the privacy practices of Google, please visit the Google Privacy & Terms web page

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You have the right to review, update or delete any of your personal data by sending a request at NIPD Genetics Personal Data Officer pdo@nipd.com

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Our Sites may contain links to other sites that are not operated by us. If you click on a third-party link, you will be directed to that third party's site. We strongly advise you to review the Privacy Policy of every site you visit.

We have no control over and assume no responsibility for the content, privacy policies or practices of any third-party sites or services.

Children's Privacy

Our Service does not address anyone under the age of 18 ("Children").

We do not knowingly collect personally identifiable information from anyone under the age of 18. If you are a parent or guardian and you are aware that your Children has provided us with Personal Data, please contact us. If we become aware that we have collected Personal Data from children without verification of parental consent, we take steps to remove that information from our servers.

Changes to This Privacy Policy

We may update our Privacy Policy from time to time. We will notify you of any changes by posting the new Privacy Policy on this page.

We will let you know via email and/or a prominent notice on our Service, prior to the change becoming effective and update the "effective date" at the top of this Privacy Policy.

You are advised to review this Privacy Policy periodically for any changes. Changes to this Privacy Policy are effective when they are posted on this page.

Contact Us

If you have any questions about this Privacy Policy, please contact pdo@nipd.com

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