Rodinia is a genetic test for infertility that screens for mutations in
individuals who have difficulty achieving pregnancy. By
identifying genetic variants associated with infertility and disorders
of sex chromosomes, Rodinia can provide accurate prognostic assessment and
identify the most applicable treatment options for each patient. Rodinia
can help guide you towards an optimal treatment plan for any couple or
individual wishing to have a child.
WHAT DOES Rodinia TEST FOR?
Rodinia offers a Female and a Male Infertility Panel. Each panel detects numerous genetic variants associated with infertility. Rodinia also detects whole, partial and mosaic sex chromosome changes.
In addition, Rodinia provides a Thrombophilia and NAIT Panel that could be offered either as an Add-on to the Female or Male Panel, or as a Stand-alone Panel.
FEMALE INFERTILITY PANEL
55 genes, X chromosome aneuploidies
Screens for genetic variants associated with female infertility
and includes disorders such as primary ovarian
insufficiency, polycystic ovary syndrome, ovarian
hyperstimulation syndrome and hypogonadotropic hypogonadism disorders such as Kallman syndrome.
Early interventions to preserve fertility:
Early identification of women with primary ovarian insufficiency can determine the need for oocyte harvesting and
cyropreservation at a young age to preserve fertility
and enable the patient to have a child in the future.
MALE INFERTILITY PANEL
40 genes, X and Y chromosome aneuploidies, including Y-chromosome microdeletions
Screens for genetic variants that can cause male factor inferitlity, including sex chromosome changes
and hypogonadotropic hypogonadism disorders like Kallman syndrome.
Prognostic value for treatment: Azoospermic men have a higher prevalence of microdeletions on the Y-chromosome than men with normal sperm and should
receive genetic testing to clarify etiology prior to treatment*. Of the 3 deletions that are associated with azoospermia, only one is associated with
a chance of recovering sperm through testicular sperm extraction treatment
THROMBOPHILIA & NAIT PANEL
22 genetic variants
Checks for specific genetic variants associated with recurrent pregnancy loss. Can be offered to couples or individuals that have had more than one miscarriage, or have a family history of Neonatal Alloimmune Thrombocytopenia (NAIT), among other reasons.
Can be selected as an Add-on Panel to the Female or Male Panel, or as a Stand-alone Panel.
Guidance on treatment decisions: Identifying variants associated with recurrent pregnancy loss can determine the need for taking treatment, such as hormonal therapy or anticoagulants, which may reduce or prevent complications during pregnancy and delivery.
*Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile male: a committee opinion (2015)
Couples or individuals experiencing
Individuals with specific phenotype indicating a genetic syndrome associated with a sex chromosome aneuploidy
Females with irregular or absent menstruation
Males with low sperm count, irregular sperm form, or movement
Any individual or couple that will undergo assisted reproductive technology (ART) treatment
Candidates for sperm or oocyte donation
Individuals with family history of infertility
Couples or individuals with more than one miscarriage Applicable only for the Thrombophilia & NAIT panel
HOW DOES GENETIC TESTING HELP ME?
Biochemical and instrumental testing, such as hormone checks, ultrasounds and semen analysis can identify up to 65% of infertility cases. If the cause of infertility remains undetermined, genetic testing can be offered as a significant
number of infertility cases are attributed to genetic variants.
Up to 15% of men and up to 10% in women have a genetic mutation which is linked with infertility. Genetic testing can provide deep
insight that acts as a valuable prognostic tool, and can guide you to take informed and accurate decisions on
the best clinical management and treatment for your patient. Genetic testing could subsequently help increase
the patient's chances for achieving a pregnancy.
X and Y chromosome analysis for whole copy number changes, and partial changes down to 10Mb
Mosaicism detection in sex chromosomes down to 15%
Full coverage of all coding regions, detecting single nucleotide variants, small insertions and deletions, and copy number variants
The Thrombophilia & NAIT panel targets specific variants
Novel bioinformatics for high sensitivity and specificity
WHAT WILL THE REPORT TELL ME?
Results on mutations tested
Thorough interpretation and clinical significance
of variants detected
Reporting pathogenic and likely pathogenic variants,
and variants of uncertain significance
Carrier status will not be reported for recessive conditions.
The Thrombophilia & NAIT panel reports the genotype for the variants tested.
WHAT CAN I DO AFTER Rodinia ?
By identifying the underlying genetic cause of infertility, Rodinia can help you to:
Determine accurate prognosis for your patient
Evaluate and choose the most optimal treatment for your patient
Manage clinical care by being aware of potential complications, like ovarian hyperstimulation
Advice your patient on how to proceed with pregnancy planning
Recommend testing to family members, if applicable
WHY RECOMMEND Rodinia TO MY PATIENTS?
Infertility is considered a major disorder of the reproductive system and it affects approximately 1 in 6 couples worldwide†.
Rodinia uses robust and proven technology to detect mutations on genes associated with infertility and changes
on sex chromosomes. Rodinia can provide important insight regarding the reproductive health of an individual and guide treatment
options to help them achieve conception.
Early detection of the underlying genetic cause of infertility can act as a prognostic tool and be pivotal to the choice and outcome of treatment.
Early detection can also determine the need for earlier interventions at a younger age, to
Rodinia provides invaluable genetic insight which can guide you to create a more personalized approach for family planning for each couple or individual.
Superior targeted genomic analysis
Identifies genetic mutations associated with infertility
Guides patient-specific clinical management and treatment
Enables accurate prognosis
Easy to interpret results
High precision and accuracy
†Agarwal A., et al., 'A unique view on male infertility around the globe'. Reproductive biology and endocrinology, 2015.
HOW TO ADMINISTER
RECOMMEND Rodinia TO YOUR PATIENT
COLLECT A BUCCAL SWAB FROM YOUR PATIENT
SEND THE SAMPLE TO NIPD Genetics
THE SAMPLE WILL BE ANALYZED IN OUR LABORATORIES
RESULTS WILL BE SENT TO YOU WITHIN 2-4 WEEKS FROM SAMPLE RECEIPT
NIPD Genetics is a leading, innovative biotechnology company that designs, develops, and provides a
broad spectrum of healthcare services to its customers through its expansive portfolio of molecular
and clinical laboratory tests in all disciplines.
At NIPD Genetics we are committed to protecting and respecting our customer’s privacy and personal
information. Personal information or personal data means any information that identifies, relates to,
describes, is capable of being associated with, or could be reasonably linked, directly or indirectly, with
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one or more factors specific to the physical, physiological, genetic, mental, economic, cultural or social
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NIPD Genetics collects and processes your personal information according to the General Data
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persons with regards to the processing of personal data and for the free movement of such data (L.
125(I)/2018). The following principles lie at the heart of our approach to handling personal data:
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and up to date.
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details of the Data Protection Officer (DPO) can be found below:
Postal address: 31 Neas Engomis street, 2409 Engomi, Nicosia, Cyprus
Telephone number: + 357 22266888
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We collect and process several types of personal information from and about users of our websites
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Personal and sensitive information: some of our products and services may involve testing
biological samples that we or our customers use to create test reports, genotyping or sequencing
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data derived from samples, including through our customer’s use of our software as a service
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The technologies we use for this automatic data collection may include cookies. You can control
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If you are under 18 years of age, do not register on our website or provide any information about
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their personal information. Despite this prohibition, it is possible that we may sometimes be given
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use of our products and services by our customers and partners. If we become aware that we have
inadvertently collected personal information from children under the age of 18, without parental
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Your personal information is collected by NIPD Genetics for the following purposes:
To provide you with our products and services, respond to your inquiries or fulfill your requests
and otherwise manage your relationship with us. The legal basis for processing is to meet the
requirements of a contract, to comply with our legal obligations and/or because we have a
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To communicate with you about content and product offerings, newsletters and event invitations
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To monitor and record information relating to the use of our products and services, including our
website. The legal basis for processing is our legitimate interest in order to improve our products
and services and our website for individuals.
To provide our products and services, NIPD Genetics may collect, receive and process biological
samples to isolate and sequence DNA. NIPD Genetics may then store resulting genetic information
and use genetic information to provide our products and services. In some cases, NIPD Genetics may
provide interpretations of genetic information on behalf of its customers, including healthcare
providers. This is only done pursuant to a written contract or a Sample Information Form with a
patient’s informed consent and is subject to applicable legal and ethical safeguards.
This sensitive information described above is collected by NIPD Genetics for the following purposes:
To provide support and maintenance services to customers who use our products and services –
The legal basis for processing is to meet the requirements of a contract.
To provide genotyping and sequencing services and analysis for our customers, including
healthcare providers. The legal basis of this processing is to meet the requirements of a contract
or as allowed in the Sample Information Form with a patient’s informed consent.
To conduct genotyping and sequencing services and analysis for quality control, process and
product development and improvements, and optimization in our labs to reflect quality
improvements and advances in our technology. The legal basis for processing is the patient’s
informed consent given through the Sample Information Form.
Transfer of Data
Your information, including personal data, may be transferred to - and maintained on - computers
located outside your province, country or other governmental jurisdiction where the data protection
laws may differ than those from your jurisdiction.
If you are located outside Cyprus and choose to provide information to us, please note that we transfer
the data, including personal data, to Cyprus and process it there.
agreement to that transfer.
NIPD Genetics will take all reasonable steps necessary to ensure that your data is treated securely and
an organization or a country unless there are adequate controls in place including the security of your
data and other personal information.
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NIPD Genetics complies with the General Data Protection Regulation and will not sell or trade your
NIPD Genetics may disclose your personal information in the good faith that such action is necessary:
To comply with a legal obligation
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We may use third-party Service Providers to monitor and analyze the use of our websites.
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Google uses the data collected to track and monitor the use of our service. This data is shared with
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You can opt-out of having made your activity on the Service available to Google Analytics by installing
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For more information on the privacy practices of Google, please visit the Google Privacy & Terms web
SECURITY OF DATA
We are committed to protecting the security of the information we collect, and we take reasonable
physical, technical, and administrative safeguards such as data anonymization and encryption to help
protect personal information from unauthorized or inappropriate access or use. It is your
responsibility to protect the confidentiality of your passwords, and any other access features
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PERSONAL DATA RETENTION
We may retain collected information even after you remove it from the website, our Services, or our
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Use, or an applicable contract between us and you or your organization. How long we retain specific
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personal information in accordance with applicable law.
We may employ third party companies and individuals to facilitate, maintain or operate our websites
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These third parties have access to your Personal Data only to perform these tasks on our behalf and
are obligated not to disclose or use it for any other purpose.
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Our websites may contain links to other sites that are not operated by us. If you click on a third-party
of every site you visit.
We have no control over and assume no responsibility for the content, privacy policies or practices of
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We will let you know via email and/or a prominent notice on our website, prior to the change
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NIPD Genetics ensures that it can respond immediately to requests that you make for the exercise of
your legal rights in accordance with data protection laws. These rights are as follows:
The right to withdraw consent at any time – in cases where processing is based on your
The right of access – at any given time you have the right to know what information about you
we hold and receive information about the processing activities we perform
The right to rectify – you have the right to correct, amend and complete personal data that is
The right to erasure (“right to be forgotten”) – you can request that your personal information
The right to object – you can object at any time to our processing of your personal information
The right to restriction of processing – this applies in the event:
You dispute the accuracy of your personal information and until it is verified
You oppose to the deletion of personal data and ask instead to delete the use of it
The personal information is no longer necessary for us
You object to the processing and we are considering whether our legitimate grounds
for processing prevail over the reasons you oppose to the processing
The right to data portability – at any given time you have the right to receive the personal
information we hold about you in a structured, commonly used and machine-readable format
(pdf, word etc.). You also have the right to request that these data are transferred to another
service in a safe and secure way
You also have the right to lodge a complaint at any time to the Office of the Commissioner for Personal
We encourage you to contact us, should you wish to practice any of your legal rights or you have any