WHAT IS Amfira PGT?
Amfira is a preimplantation genetic test (PGT) that can determine whether an embryo created through in vitro fertilization (IVF) is chromosomally normal (euploid). Choosing to implant a euploid embryo can increase the chances of having a healthy pregnancy and live birth, and potentially reduce the number of IVF cycles and time needed to achieve pregnancy.
WHY RECOMMEND Amfira PGT TO MY PATIENTS?
Amfira PGT identifies chromosomally normal embryos which can:
- Increase the chances of successful implantation
- Increase the chances of healthy live births
- Lower miscarriage rate
- Lead to safer pregnancies, with fewer maternal and perinatal complications by promoting single embryo transfers (SET)
- Achieve a pregnancy earlier compared to cycles without PGT
AMFIRA PGT PANELS
PGT-A: PGT for AneuploidiesFor everyone going through IVF.
PGT-A identifies embryos that are euploid and have the highest potential for resulting to a healthy livebirth. Amfira PGT-A panel tests all 23 pairs of chromosomes.
PGT-SR: PGT for Structural Rearrangements(includes PGT-A analysis)
For people who have been diagnosed with a balanced chromosomal rearrangement (translocation) and are at a higher risk of having implantation failures, recurrent pregnancy loss or a child with a chromosomal disorder.
PGT-SR identifies embryos that are euploid or balanced for the translocation, and have better prospects of leading to a healthy pregnancy with lower risk of miscarriages. Amfira PGT-SR panel includes PGT-A analysis and tests all 23 chromosomal pairs, including the ones involved in the translocation, with a high resolution of more than 10 Mb.
WHO IS Amfira PGT FOR?
WHY ADD Amfira PGT TO MY PATIENTS' IVF CYCLE?
Chromosomal aneuploidy in embryos increases with advanced maternal age, and negatively impacts implantation rates. PGT cannot correct embryos with a chromosomal aneuploidy. Knowing which embryos are chromosomally normal will allow you to implant those embryos over chromosomally abnormal embryos. Euploid embryos have higher chances of implantation, less risk of resulting in miscarriages and better potential for a healthy live birth.
Amfira PGT could raise the chance of your patients having a healthy baby earlier, by reducing the number of IVF cycles and the time needed to achieve a pregnancy.
TRUSTED TECHNOLOGY, DEPENDABLE RESULTS
Amfira is built on NIPD Genetics proprietary Target Capture Enrichment Technology using Next Generation Sequencing (NGS), which has been extensively validated for its exceptionally high accuracy, sensitivity and specificity.
DETECTION OF SELECTED MALE POLYPLOIDIES
WHAT WILL Amfira PGT TELL ME?
Amfira PGT analyzes all 23 chromosomal pairs of an embryo, and reports whether the sample tested is euploid, aneuploid or mosaic.
Euploid: An embryo which is chromosomally normal, having in total 46 chromosomes. Euploid embryos have the best chance of implantation, successful pregnancy and healthy live births.
Aneuploid: An embryo with additonal or fewer chromosomes than the correct number.
- Whole chromosome aneuploidy: an entire chromosome is either missing (monosomy - 1 copy) or is extra (trisomy - 3 copies).
- Segmental aneuploidy: part of a chromosome is missing (deletion), or is extra (duplication). The development of the embryo, its survival, implantation potential, miscarriage risk and whether a baby with a chromosomal abnormality is born, depend on whether the aneuploidy is whole or segmental, and on the affected chromosome.
Mosaic: An embryo which has the correct number of chromosomes in some of its cells, and an incorrect number of chromosomes in others. Mosaicism is a biological limitation that cannot be overcome with any current technology. Mosaic embryos may still result in a viable pregnancy. The development of the embryo and the health of the baby depend on whether the fetus shares the mosaic cell lineage as the trophectoderm, and on the chromosome affected by mosaicism.
HOW DOES Amfira PGT HELP ME?
More and more data demonstrate that robust, reliable and fast chromosomal assessment of embryos in addition to morphological grading can result in improved assessement of embryo ploidy and higher implantation potential.
Contrary to other technologies, the recent introduction of Next Generation Sequencing (NGS) for PGT has shown improved efficiency and precision.
With Amfira PGT, you can take informed decisions based on accurate and reliable information that will benefit your patients and help you increase your implantation and live birth rates.
Amfira PGT CAN HELP INCREASE THE CHANCES OF A SUCCESSFUL PREGNANCY FOR WOMEN OF ALL AGES
Embryo aneuploidy, which increases with maternal age, is the primary cause of miscarriage in women, accounting for up to 70% of pregnancy losses*.
Unlike whole chromosome aneuploidies, segmental changes and mosaicism are not shown to be linked to advanced maternal age, thus having PGT can be beneficial for women of all ages.
The graph above shows the advantage of identifying and transferring a euploid embryo, where one exists, in regards to live births.
The graph shows the advantage of identifying and transferring a euploid embryo, in regards to miscarriage rate.
* Silver R.M. and Branch D. (2007)
* Data obtained from the Preliminary National Summary Report for 2018 of the Society for Assisted Reproductive Technology (SART) and summarize data per transfer for first embryo transfers using patients' own eggs.
HOW DOES Amfira PGT WORK?
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You may contact NIPD Genetics Public Company Ltd at
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NIPD Genetics Data Protection Officer can be reached at email@example.com
- Type of personal information NIPD Genetics may collect through its Sites
- The ways by which NIPD Genetics collects, uses or shares such information
- Steps NIPD Genetics takes to protect its sites’ users personal information
This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Sites and the choices you have associated with that data.
Type of personal information NIPD Genetics may collect through its Sites
Information Collection And Use
We collect several different types of information for various purposes to provide and improve our Sites and services to you.
While using NIPD Genetics Sites, you may be asked to provide NIPD Genetics certain personally identifiable information that can be used to contact or identify you ("Personal Information"). Personal Information that might be used to identify you includes, but is not limited to:
- Email address
- First name and last name
- Phone number
- Address, State, Province, ZIP/Postal code, City
- IP address
If you send us a query via our Contact us form, your email address, the content and any follow up emails are retained indefinitely.
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We may also collect information how the Sites are accessed and used ("Usage Data"). This Usage Data may include information such as your computer's Internet Protocol address (e.g. IP address), browser type, browser version, the pages of our Sites that you visit, the time and date of your visit, the time spent on those pages, unique device identifiers and other diagnostic data.
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Cookies are files with small amount of data which may include an anonymous unique identifier. Cookies are sent to your browser from a website and stored on your device. Tracking technologies also used are beacons, tags, and scripts to collect and track information and to improve and analyze our Sites.
You can instruct your browser to refuse all cookies or to indicate when a cookie is being sent. However, if you do not accept cookies, you may not be able to use some portions of our Sites.
Examples of Cookies we use:
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www.nipd.com uses the collected data for various purposes:
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- To provide analysis or valuable information so that we can improve the Sites
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- To detect, prevent and address technical issues
Transfer of Data
Your information, including personal data, may be transferred to — and maintained on — computers located outside of your province, country or other governmental jurisdiction where the data protection laws may differ than those from your jurisdiction.
If you are located outside Cyprus and choose to provide information to us, please note that we transfer the data, including personal data, to Cyprus and process it there.
Disclosure of Data
NIPD Genetics complies with the protection of personal data regulation and will not sale or trade your personal data.
NIPD Genetics may disclose your personal data in the good faith belief that such action is necessary to:
- To comply with a legal obligation
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Security of Data
The security of your data is important to us, but remember that no method of transmission over the Internet, or method of electronic storage is 100% secure. While we strive to use commercially acceptable means to protect your Personal Data, we cannot guarantee its absolute security.
We may employ third party companies and individuals to facilitate, maintain or operate our Sites ("Service Providers"), to provide the SItes on our behalf, to perform service-related services or to assist us in analyzing how our Sites is used.
These third parties have access to your Personal Data only to perform these tasks on our behalf and are obligated not to disclose or use it for any other purpose.
We may use third-party Service Providers to monitor and analyze the use of our Sites.
Google Analytics is a web analytics service offered by Google that tracks and reports website traffic. Google uses the data collected to track and monitor the use of our Service. This data is shared with other Google services. Google may use the collected data to contextualize and personalize the ads of its own advertising network.
For more information on the privacy practices of Google, please visit the Google Privacy & Terms web page
Access to your personal data, correction, deletion, and Opting Out
Links to Other Sites
We have no control over and assume no responsibility for the content, privacy policies or practices of any third-party sites or services.
Our Service does not address anyone under the age of 18 ("Children").
We do not knowingly collect personally identifiable information from anyone under the age of 18. If you are a parent or guardian and you are aware that your Children has provided us with Personal Data, please contact us. If we become aware that we have collected Personal Data from children without verification of parental consent, we take steps to remove that information from our servers.