WHAT IS Ventrilia?

Ventrilia is a new generation genetic test that analyzes 292 genes to detect mutations that cause multiple cardiovascular conditions with complex phenotypes. By identifying genetic mutations that could cause cardiovascular diseases, Ventrilia can provide you with comprehensive genetic insight about your patient’s cardiovascular health and guide you towards an optimal clinical management plan.

Ventrilia CAN BE USED TO:

  • Identify the genetic variant in symptomatic individuals with a clinically diagnosed cardiovascular condition
  • Identify the genetic variant in presymptomatic individuals with a clinically diagnosed cardiovascular condition
  • Identify the genetic variant in asymptomatic individuals that belong in high-risk groups

ADVANTAGES OF Ventrilia INCLUDE:

  • Assessment of clinically actionable mutations
  • Proven technology
  • Superior targeted genomic analysis
  • Easy to interpret results
  • Competitive turn-around time
  • Informed clinical management
  • Non-Invasive sample collection

CARDIOVASCULAR DISEASE PANELS

Ventrilia tests for autosomal recessive, autosomal dominant, and X-linked cardiovascular diseases.

  • AORTOPATHY

    48

  • ARRHYTHMIA

    42

  • CARDIOMYOPATHY

    98

  • CONGENITAL HEART DEFECTS (CHD)

    80

  • FAMILIAL HYPERCHOLESTE­RO­LEMIA (FH)

    11

  • PULMONARY HYPERTENSION (PH)

    11

  • RASOPATHIES

    30

  • COMPREHENSIVE

    292

ARRHYTHMIA PANEL

Arrhythmia refers to irregular, too fast, or too slow heartbeat caused by the improper working of the electrical impulses that coordinate the heartbeat. Arrhythmia related diseases include: Atrial Fibrillation, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Long QT Syndrome, Short QT Syndrome

Number Of Genes Tested

42

CARDIOMYOPATHY PANEL

Cardiomyopathy is a group of diseases of the heart muscle (myocardium) which reduces the efficiency of the heart to pump blood. Cardiomyopathy related diseases include: Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathy with onset in neonatal period, infancy or childhood, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Non-Compaction Cardiomyopathy, Restrictive Cardiomyopathy

Number Of Genes Tested

98

CONGENITAL HEART DEFECTS (CHD) PANEL

Congenital heart defects are present from birth and affect the heart’s structure and efficiency to function. CHD related diseases include: Atrioventricular Septal defect, Atrial Septal defect, Ventricular Septal defect, Aortic Stenosis, Tetralogy of Fallot.

Number Of Genes Tested

80

RASOPATHIES PANEL

RASopathies are a group of genetic conditions that affect the RAS-MAPK pathways and lead to developmental syndromes. RASopathies related diseases include: Cardio-Facio-Cutaneous Syndrome, Costello Syndrome, Legius Syndrome, Neurofibromatosis Type 1, Noonan Syndrome, Noonan with multiple lentigines

Number Of Genes Tested

30

AORTOPATHY PANEL

Aortopathy refers to a group of diseases that affect the aorta, causing enlargement, dissection or aortic aneurysm. Aortopathy related diseases include: Marfan Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome, Familial Thoracic Aortic Aneurysms and Dissections, Bicuspid Aortic Valve Disease.

Number Of Genes Tested

48

FAMILIAL HYPERCHOLESTEROLEMIA (FH) PANEL

Familial Hypercholesterolemia is a common inherited genetic disorder that causes high levels of LDL and could lead to heart disease and heart attacks, if untreated.

Number Of Genes Tested

11

PULMONARY HYPERTENSION (PH) PANEL

Pulmonary Hypertension refers to the high blood pressure in the arteries of the lungs and the right side of the heart.

Number Of Genes Tested

11

COMPREHENSIVE PANEL

The comprehensive panel includes all 292 genes tested in the disease panels.

Number Of Genes Tested

292

For a complete list of 292 genes tested by Ventrilia, please click here.

WHY RECOMMEND Ventrilia TO MY PATIENTS?

Cardiovascular diseases are the leading cause of illness and death worldwide, responsible for 31% of all global deaths*. Previously, assessment of the disease risk was based on the lifestyle of an individual. The role of genetic testing is now becoming increasingly important. Genetic testing can detect the underlying condition, provide a prognosis and identify at-risk family members, who might be predisposed to the same cardiovascular disease. Identification of a genetic mutation that causes a disease, can lead to an improved prognosis as well as effective clinical management and treatment for many cardiovascular conditions.

Cardiovascular genetic testing is highly recommended by professional societies such as the American College of Cardiology (ACC), American Heart Association (AHA), and the European Society of Cardiology (ESC).

* World Health Organization (Cardiovascular Diseases fact sheets) and World Heart Federation (2017)

Clinical Appropriateness Guidelines - Genetic Testing for Hereditary Cardiac Disease - developed by Informed Medical Decisions, Inc.(2019)

WHAT IS THE ROLE OF CARDIOVASCULAR GENETIC TESTING?

IDENTIFY

  • Genetic mutations involved in cardiovascular conditions
  • Complex cardiovascular diseases
  • The correct disease by differentiating between diseases with similar phenotype

EVALUATE

  • Patient's level of risk
  • Treatment options
  • At-risk family members

MANAGE

  • Clinical care
  • Decision-making before an invasive treatment
  • Specific therapies and predict their response

WHO IS Ventrilia FOR?

Symptomatic patients with an unidentified cardiovascular genetic disorder

Presymptomatic patients with family history of inherited cardiovascular disease or sudden cardiac death

Patients experiencing fainting or unexplained seizures

Patients with clinical diagnosis of aortic defect, or irregular cardiovascular anatomy

Patients with clinical diagnosis of channelopathies (irregular heart rhythm)

Patients suspected of having a cardiovascular-associated genetic condition due to clinical symptoms (shortness of breath, excessive sweating, heart pain, weakness)

Patients in high-risk groups (eg. high cholesterol) with non-specific phenotype

TECHNOLOGY YOU TRUST

Ventrilia uses a targeted genomic analysis and a robust, validated multiengine analysis platform to screen for clinically actionable, highly penetrant gene mutations with high sensitivity and specificity.

TARGETED TECHNOLOGY

Ventrilia is based on a novel, target capture enrichment technology that has been thoroughly validated for its accuracy and precision.

FULL COVERAGE

Ventrilia screens for all coding regions on the genes of interest, increasing the chances of identifying any pathogenic or likely pathogenic mutations: single nucleotide variants, small insertions and deletions, and copy number variants.

NOVEL BIOINFORMATICS

Innovative bioinformatics pipelines analyze the sequencing data produced from each sample, increasing the sensitivity and specificity of Ventrilia.

WHAT WILL THE REPORT TELL ME?

  • Result on mutations tested
  • Thorough interpretation and clinical significance of variants

Carrier status will not be reported for recessive conditions. Re-interpretation of variants of uncertain significance will be performed at routine intervals.

HOW DOES Ventrilia HELP ME?

Overlapping symptoms make it very challenging to clearly identify the underlying cardiovascular condition. There are many types of congenital cardiovascular diseases, ranging from simple to complex defects with severe, life-threatening symptoms.

Ventrilia can detect mutations that cause cardiovascular diseases and help you choose an ideal treatment based on the specific mutation, develop a better clinical management plan and reduce your patient's risk of sudden cardiovascular events such as stroke or heart attack.

For high-risk, asymptomatic individuals with a cardiovascular genetic mutation, you can recommend appropriate examinations at key time intervals. Additionally, you can inform any family members who might also have the same genetic mutation. Early intervention can potentially be lifesaving for symptomatic, presymptomatic and asymptomatic individuals.

WHAT ARE THE BENEFITS OF Ventrilia FOR MY PATIENTS?

  • Faster identification of complex cardiovascular conditions
  • Accurate detection of multiple cardiovascular genetic mutations
  • Early identification in asymptomatic patients
  • Improved prognosis
  • More effective treatment
  • Better clinical care
  • Prevention of potential sudden onset of cardiovascular conditions, including sudden death in all patients

HOW TO ADMINISTER Ventrilia?

  • RECOMMEND THE IDEAL PANEL TO YOUR PATIENT
  • COLLECT A BUCCAL SWAB FROM YOUR PATIENT
  • SEND THE SAMPLE TO NIPD Genetics
  • THE SAMPLE WILL BE ANALYZED IN OUR LABORATORY
  • RESULTS WILL BE SENT TO YOU WITHIN 2-4 WEEKS FROM SAMPLE RECEIPT

NIPD Genetics - Privacy Policy

General Statement

This Privacy Policy applies only to www.nipd.com and its subdomains (hereafter collectively referred to as “Sites") that link to this policy. NIPD Genetics Sites are owned by NIPD Genetics Public Company Ltd and are operated by NIPD Genetics Public Company Ltd and on occasion by a third-party that is responsible for the technical maintenance of the Sites.

If, you do not agree with this Privacy Policy, please do not access or use any of NIPD Genetics Sites.

NIPD Genetics values your interest in NIPD Genetics, its products and its services. NIPD Genetics takes the protection of your data seriously.

Personal data for purposes of this Privacy Policy, is any information by which you can be individually identified, including, but not limited to, your name, profession, address, e-mail address, and telephone number.

You may contact NIPD Genetics Public Company Ltd at
NIPD Genetics Public Company Ltd
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NIPD Genetics Data Protection Officer can be reached at dpo@nipd.com

This Privacy Policy applies only to the Sites as defined above and which are operated by NIPD Genetics. The NIPD Genetics Privacy Policy seeks to inform the users of its Sites of the following:

NIPD Genetics will not use or share your information with anyone, except as described in this Privacy Policy. This Privacy Policy does not apply to any information we might collect by other digital and offline means and or from other digital and offline sources. The use of information collected through our Sites shall be limited to the purposes under this Privacy Policy and our Terms of Use to customers.

This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Sites and the choices you have associated with that data.

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Type of personal information NIPD Genetics may collect through its Sites

Information Collection And Use

We collect several different types of information for various purposes to provide and improve our Sites and services to you.

Personal Data

While using NIPD Genetics Sites, you may be asked to provide NIPD Genetics certain personally identifiable information that can be used to contact or identify you ("Personal Information"). Personal Information that might be used to identify you includes, but is not limited to:

If you send us a query via our Contact us form, your email address, the content and any follow up emails are retained indefinitely.

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We may also collect information how the Sites are accessed and used ("Usage Data"). This Usage Data may include information such as your computer's Internet Protocol address (e.g. IP address), browser type, browser version, the pages of our Sites that you visit, the time and date of your visit, the time spent on those pages, unique device identifiers and other diagnostic data.

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Your information, including personal data, may be transferred to — and maintained on — computers located outside of your province, country or other governmental jurisdiction where the data protection laws may differ than those from your jurisdiction.

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Your consent to this Privacy Policy followed by your submission of such information represents your agreement to that transfer.

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NIPD Genetics may disclose your personal data in the good faith belief that such action is necessary to:

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You can opt-out of having made your activity on the Service available to Google Analytics by installing the Google Analytics opt-out browser add-on. The add-on prevents the Google Analytics JavaScript (ga.js, analytics.js, and dc.js) from sharing information with Google Analytics about visits activity.

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You have the right to review, update or delete any of your personal data by sending a request at NIPD Genetics Personal Data Officer pdo@nipd.com

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Our Service does not address anyone under the age of 18 ("Children").

We do not knowingly collect personally identifiable information from anyone under the age of 18. If you are a parent or guardian and you are aware that your Children has provided us with Personal Data, please contact us. If we become aware that we have collected Personal Data from children without verification of parental consent, we take steps to remove that information from our servers.

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We may update our Privacy Policy from time to time. We will notify you of any changes by posting the new Privacy Policy on this page.

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You are advised to review this Privacy Policy periodically for any changes. Changes to this Privacy Policy are effective when they are posted on this page.

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If you have any questions about this Privacy Policy, please contact pdo@nipd.com

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