WHAT ARE THE BENEFITS OF Oreana NEONATAL SCREENING?
With Oreana, early detection of life-altering disorders can benefit the infant’s health and quality of life. The initial symptoms for many of these disorders include vomiting, lack of energy, breathing problems, feeding diffculties, and episodes of metabolic crises that require urgent care. Although treatment can begin when infants first start showing symptoms, which may be a few weeks or months after birth, their growth and development will already be impacted. Early detection and starting treatment as soon as possible is the most favourable way to prevent symptoms or minimise the impact of the condition.
Early detection can:
- Prevent or minimize symptoms
- Reduce the impact of the condition
- Reduce the time spent for diagnosis, and prevent a late diagnosis
- Permit early clinical interventions, treatment and management which will be more beneficial for the infant
- Enable potential participation of the infant in experimental therapies or clinical trials
WHY CHOOSE Oreana NEONATAL SCREENING?
Results are reported quickly, so if necessary, your baby can start beneficial treatment as soon as possible
Tests for disease-causing genetic changes (mutations), that cause serious health problems
Superior technology that yields accurate results
Non-invasive and painless for the infant
Complements newborn screening programs that test a smaller number of disorders
A MANAGEABLE CONDITION IS IDENTIFIED IN ABOUT 1 in 300 NEWBORNS*
Oreana neonatal screening can detect treatable or manageable conditions before appearance of symptoms. With early treatment and management, symptoms can be averted, and health problems can be minimized or prevented. Oreana can also be used for newborns, infants and children who show symptoms of a genetic disease which could be diffcult to identify. In these cases, Oreana can lead to the appropriate therapy that will benefit the affected child.
*Data collected from Centers for Disease Control and Prevention (2012); CDC Grand Rounds: Newborn screening and improved outcomes, and is based on screening of 29 diseases included in core conditions of the Recommended Uniform Screening Panel.
WHY PERFORM Oreana IN ADDITION TO NATIONAL NEWBORN SCREENING?
National newborn screening programs offer great advantages for infants, their families and national health systems. However, since they are subjected to each country’s regulations, the structure of the healthcare system and available funds, there are vast differences in the number of conditions each country tests for and in the technology they use to do so. As a result, countries throughout the world perform newborn ranging from only 2 disorders to over 35.
Oreana neonatal screening tests for 142 genes associated with genetic disorders that are either treatable or can benefit from early detection. Among others, Oreana tests for metabolic, endocrine, haemoglobin and hearing loss disorders, whose early detection and management can lead to therapeutic treatments that could reduce the severity of symptoms and improve the prognosis and life quality of the affected infant.
HOW IS TESTING PERFORMED?
Testing is quick and safe for your baby. A healthcare practitioner will use a specialized, soft swab to collect sample from the inside of the cheek of the infant, by moving it around in circular movements. The procedure is painless and is completed in a few seconds. The results will be reported back to your healthcare practitioner within 2-3 weeks of sample receipt.
WHEN IS THE IDEAL TIME FOR TESTING?
Your baby can get tested anytime after birth, up until early childhood. Ideally, the earlier the infant is tested, the sooner you will know whether they are affected, and start beneficial treatments that can prevent the onset of symptoms or minimize the impact of the disease.
WHAT DOES Oreana TEST FOR?
Oreana tests for 142 genes associated with genetic disorders that when detected early, can prevent or reduce serious consequences such as developmental delay, cognitive impairment, neurological and physical problems and premature death. The conditions tested may be inherited from carrier parents who are unaware of their carrier status to their children, or without a known or prior family history of that disorder.
Lifelong dietary management is required. Early diagnosis and interventions can help prevent symptoms and improve prognosis.
Early medical treatment and interventions can improve thyroid function, growth, development and metabolism. Lifelong treatment and follow-up by specialists is necessary.
Medical treatment, dietary management and transfusions are critical and needed lifelong.
HEARING LOSS DISORDERS
Hearing aids, cochlear implants or other services can help with creating the best management plan. Early interventions can improve the speech, language and social skills of affected children.
IMMUNODEFICIENCY, PULMONARY OR MUSCULOSKELETAL DISORDERS
Including Cystic Fibrosis, Severe Combined Immunodeficiences and Spinal Muscular Atrophy. Early detection is critical for prompt medical treatment, such as bone marrow transplantation, and better prognosis.
Oreana tests for 142 genes of Autosomal Recessive, Autosomal Dominant and X-Linked disorders. The disorders tested by Oreana are included in the 'Recommended Uniform Screening Panel', a list of disorders selected based upon the recommendations of the American College of Medical Genetics (ACMG) for newborn screening. Additional, clinically significant, manageable disorders were added to the Oreana panel.